Session Chair and Speaker
Flora Vaccarino, Yale School of Medicine, USA
Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as neuropharmacology fellow at NIH, trained in clinical psychiatry at Yale, and then was a research fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to assistant, associate and full professor. Having studied mammalian brain development in animal models for over 20 years, she now leads a multidisciplinary research group focusing on the study of human brain development, using stem cell biology and genomics as tools. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) and showed that they recapitulate early fetal development of the human cerebral cortex. Using human brain organoids, Vaccarino and colleagues characterize gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in autism spectrum disorders and other neuropsychiatric diseases.
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